It's Rapid, Sensitive and Specific test
In infertile couples, male factors account for almost half of the cases of infertility [1].
A constitutional chromosomal abnormality can be found in about 15% of azoospermic men and in 6%
of men with oligozoospermia.
With the advent of testing for Y chromosome microdeletions, about 7% of those patients previously
designated "idiopathic"now have a defined cause [2}.
AZF micro-deletion was identified in infertile men with azoospermia or very lowsperm concentrations
in the ejaculate [3,4].Evaluations of Y chromosome microdeletions in infertile men with NOA (Nonobstructive azoospermia) and severe OATS ( Oligoathenoteratospermia) should be
Performed before undertaking assisted reproductive techniques, such as multiple TESE (Testicular
sperm extraction) and ICSI ( Intracytoplasmic sperm injection [2]
The test detect microdeletions in the AZFa locus (sY86, sY84 & sY615), AZFb locus (sY127, sY134
and sY142) and AZFc locus (sY1197, sY254, sY255, sY1291, sY1125, sY1206, sY242) and
AZF( azoospermiafactor).
1.Thonneau l', Marchand S, Tallec A,frrial ML, Ducot B, Lansac J, et al. Incidence and main
causes of infertility in a resident population ( 1,850,000) of three French regions ( 1988-1989).
Hum Reprod 1991;6:81 l-6.
2. Choi D, eta!., Detection of Y Chromosome Microdeletion is Valuable in the Treatment of
Patients With Nonobstructive Azoospermia and Oligoasthenoteratozoospermia: Sperm Retrieval
Rate and Birth Rate. kju.2013.54.2.1 1 1 .
3. Foresta C, Moro E, Perlin A. Y chromosome microdeletions and alterations of spermatogenesis.
Endocr Rev 2001;22:226-39. 4. Foresta C, Moro E, Perlin A. Prognostic value of Y deletion
analysis: the role of current methods. Hum Reprod 2001;16:1543-7